{"id":156,"date":"2025-07-03T20:26:38","date_gmt":"2025-07-03T11:26:38","guid":{"rendered":"https:\/\/miyamotojinnaika.jp\/blog\/?p=156"},"modified":"2025-07-03T20:26:39","modified_gmt":"2025-07-03T11:26:39","slug":"post-156","status":"publish","type":"post","link":"https:\/\/miyamotojinnaika.jp\/blog\/post-156\/","title":{"rendered":"\u7cd6\u5c3f\u75c5\u6027\u814e\u75c7\u304c\u60aa\u5316\u3059\u308b\u3068\u3001\u5fc3\u81d3\u3068\u8133\u306b\u4f55\u304c\u8d77\u304d\u308b\u306e\u304b\uff1f"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">1. \u306f\u3058\u3081\u306b<\/h2>\n\n\n\n<p>\u7cd6\u5c3f\u75c5\u6027\u814e\u75c7\u306f\u3001\u7d4c\u7cd6\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u4e0d\u826f\u306b\u3088\u308b\u814e\u7cf8\u7403\u4f53\u306e\u969c\u5bb3\u304c\u539f\u56e0\u3067\u767a\u75c7\u3057\u3001\u5c3f\u4e2d\u30a2\u30eb\u30d6\u30df\u30f3\u6392\u6cc4\uff08\u30a2\u30eb\u30d6\u30df\u30f3\u5c3f\uff09\u304b\u3089\u59cb\u307e\u308a\u3001GFR\u306e\u4f4e\u4e0b\u306b\u81f3\u308a\u307e\u3059\u3002\u814e\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u5fc3\u8840\u7ba1\u30fb\u8133\u8840\u7ba1\u7cfb\u306b\u3082\u6df1\u523b\u306a\u60aa\u5f71\u97ff\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u6700\u8fd1\u306e\u81e8\u5e8a\u30c7\u30fc\u30bf\u3067\u306f\u3001\u7cd6\u5c3f\u75c5\u6027\u814e\u75c7\u60a3\u8005\u306e\u3046\u3061\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\u306b\u3088\u308b\u6b7b\u4ea1\u30ea\u30b9\u30af\u304c\u814e\u4e0d\u5168\u306b\u3088\u308b\u3082\u306e\u3088\u308a\u3080\u3057\u308d\u9ad8\u3044\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u304a\u308a\u3001\u3053\u308c\u304c\u6cbb\u7642\u4ecb\u5165\u306e\u91cd\u8981\u6027\u3092\u7269\u8a9e\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">2. \u5fc3\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u3068\u306e\u95a2\u9023<\/h2>\n\n\n\n<p>\u6162\u6027\u814e\u81d3\u75c5\uff08CKD\uff09\u304c\u9032\u884c\u3059\u308b\u307b\u3069\u3001\u5fc3\u8840\u7ba1\u75be\u60a3\uff08CVD\uff09\u306e\u30ea\u30b9\u30af\u3082\u9855\u8457\u306b\u4e0a\u6607\u3057\u307e\u3059\u3002\u305f\u3068\u3048\u3070\u3001**Katherine R. Tuttle\u3089\u306b\u3088\u308b\u300cMoving from Evidence to Implementation of Breakthrough Therapies for Diabetic Kidney Disease\u300d\uff08Clin J Am Soc Nephrol. 2022\uff09**\u3067\u306f\u3001\u300c\u7cd6\u5c3f\u75c5\u6027\u814e\u75c7\u60a3\u8005\u306e90%\u304c\u5fc3\u4e0d\u5168\u3084\u52d5\u8108\u786c\u5316\u6027\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3067\u6b7b\u4ea1\u3057\u3001\u814e\u4e0d\u5168\u306b\u81f3\u308b\u306e\u306f10%\u306b\u3059\u304e\u306a\u3044\u300d\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059<a href=\"https:\/\/en.wikipedia.org\/wiki\/Glycated_hemoglobin?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noreferrer noopener\">en.wikipedia.org+1mdpi.com+1<\/a><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35649722\/?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noreferrer noopener\">pubmed.ncbi.nlm.nih.gov<\/a>\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">3. \u8840\u7cd6\u7ba1\u7406\u4e0d\u826f\u306b\u3088\u308b\u52d5\u8108\u786c\u5316\u4fc3\u9032<\/h2>\n\n\n\n<p>\u9ad8HbA1c\u5024\u306f\u52d5\u8108\u786c\u5316\u3092\u52a0\u901f\u3057\u3001\u51a0\u52d5\u8108\u75be\u60a3\u3084\u8133\u6897\u585e\u306e\u30ea\u30b9\u30af\u3092\u4e0a\u6607\u3055\u305b\u307e\u3059\u3002**UKPDS\uff08UK Prospective Diabetes Study\uff09\u306b\u3088\u308b\u300cAssociation of glycaemia with macrovascular and microvascular complications of type\u202f2 diabetes\u300d**\u3067\u306f\u3001HbA1c\u304c1%\u4e0a\u6607\u3059\u308b\u3054\u3068\u306b\u5fc3\u8840\u7ba1\u30ea\u30b9\u30af\u304c\u7d0414%\u4e0a\u6607\u3059\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f<a href=\"https:\/\/www.uscjournal.com\/articles\/cardiovascular-risk-type-2-diabetes-reflecting-advance-study?language_content_entity=en&amp;utm_source=chatgpt.com\" target=\"_blank\" rel=\"noreferrer noopener\">pmc.ncbi.nlm.nih.gov+2uscjournal.com+2qualitysafety-bmj-com.bibliotheek.ehb.be+2<\/a>\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u300110\u5e74\u5f8c\u306e\u8ffd\u8de1\u8abf\u67fb\uff08EDIC Study\uff09\u3067\u3082\u3001\u96c6\u4e2d\u7684\u306a\u30b0\u30eb\u30b3\u30fc\u30b9\u7ba1\u7406\u304c\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u3092\u6709\u610f\u306b\u4f4e\u6e1b\u3059\u308b\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\uff08\u201c10\u2011Year Follow\u2011up of Intensive Glucose Control in Type\u202f2&nbsp;Diabetes\u201d\uff09<a href=\"https:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa0806470?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noreferrer noopener\">ahajournals.org+15nejm.org+15uscjournal.com+15<\/a>\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">4. \u9ad8\u8840\u5727\u306e\u5f71\u97ff<\/h2>\n\n\n\n<p>\u9ad8\u8840\u5727\u306f\u7cd6\u5c3f\u75c5\u6027\u814e\u75c7\u306e\u9032\u884c\u3092\u52a0\u901f\u3055\u305b\u308b\u3060\u3051\u3067\u306a\u304f\u3001CVD\u306e\u72ec\u7acb\u3057\u305f\u30ea\u30b9\u30af\u56e0\u5b50\u3067\u3082\u3042\u308a\u307e\u3059\u3002**UKPDS\u202f38\u300cTight blood pressure control and risk of macrovascular and microvascular complications in type\u202f2 diabetes\u300d**\u306b\u3088\u308c\u3070\u3001\u8840\u5727\u3092\u53b3\u683c\u306b\u7ba1\u7406\u3059\u308b\u3068\u30de\u30af\u30ed\u30fb\u30df\u30af\u30ed\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u767a\u751f\u7387\u304c\u6709\u610f\u306b\u4f4e\u4e0b\u3057\u307e\u3057\u305f<a href=\"https:\/\/www.bmj.com\/content\/317\/7160\/703?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noreferrer noopener\">uscjournal.com+2bmj.com+2qualitysafety-bmj-com.bibliotheek.ehb.be+2<\/a>\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">5. \u8102\u8cea\u7570\u5e38\u75c7\u3068\u306e\u76f8\u4e57\u30ea\u30b9\u30af<\/h2>\n\n\n\n<p>\u7cd6\u5c3f\u75c5\u6027\u814e\u75c7\u60a3\u8005\u306b\u306f\u5178\u578b\u7684\u306b\u300c\u9ad8TG\uff0b\u4f4eHDL\uff0b\u5c0f\u578bLDL\u300d\u306e\u8102\u8cea\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u304c\u898b\u3089\u308c\u3001\u3053\u308c\u304c\u52d5\u8108\u786c\u5316\u30ea\u30b9\u30af\u3092\u5897\u5e45\u3057\u307e\u3059\u3002**\u300cDiabetic Nephropathy: Update on Pillars of Therapy Slowing Progression\u300d\uff08Diabetes Care. 2023\uff09**\u3067\u306f\u3001\u8102\u8cea\u6539\u5584\u306e\u91cd\u8981\u6027\u304c\u6307\u6458\u3055\u308c\u3066\u3044\u307e\u3059<a href=\"https:\/\/diabetesjournals.org\/care\/article\/46\/9\/1574\/153530\/Diabetic-Nephropathy-Update-on-Pillars-of-Therapy?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noreferrer noopener\">diabetesjournals.org+1mediacenteratypon.nejmgroup-production.org+1<\/a>\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001\u30b9\u30bf\u30c1\u30f3\u7642\u6cd5\u306f\u672b\u671f\u814e\u4e0d\u5168\u306b\u8fd1\u3065\u304f\u307b\u3069\u305d\u306e\u52b9\u679c\u304c\u6e1b\u5f31\u3059\u308b\u3053\u3068\u3082\u5831\u544a\u3055\u308c\u3066\u304a\u308a\u3001\u814e\u6a5f\u80fd\u4f4e\u4e0b\u6bb5\u968e\u306b\u5fdc\u3058\u305f\u6226\u7565\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">6. \u5fc3\u4e0d\u5168\u3068\u306e\u8907\u5408\u30ea\u30b9\u30af \u2014 Cardiorenal syndrome<\/h2>\n\n\n\n<p>\u814e\u6a5f\u80fd\u4f4e\u4e0b\u306b\u3088\u308b\u4f53\u6db2\u8caf\u7559\u304c\u539f\u56e0\u3067\u3001\u5fc3\u81d3\u3078\u306e\u8ca0\u8377\u304c\u5897\u3057\u3001**\u5fc3\u814e\u75c7\u5019\u7fa4\uff08cardiorenal syndrome\uff09**\u304c\u751f\u3058\u307e\u3059\u3002Tuttle\u3089\u3082\u3053\u306e\u76f8\u4e92\u4f5c\u7528\u3092\u5f37\u8abf\u3057\u3066\u304a\u308a\u3001\u7cd6\u5c3f\u75c5\u6027\u814e\u75c7\u306b\u304a\u3051\u308b\u5fc3\u4e0d\u5168\u30ea\u30b9\u30af\u306e\u9ad8\u3055\u3092\u6307\u6458\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">7. \u8133\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u306e\u5897\u5927<\/h2>\n\n\n\n<p>CKD\u60a3\u8005\u306f\u5065\u5e38\u8005\u306e2\u301c3\u500d\u306e\u8133\u5352\u4e2d\u30ea\u30b9\u30af\u3092\u62b1\u3048\u3066\u304a\u308a\u3001\u7279\u306b\u30a2\u30eb\u30d6\u30df\u30f3\u5c3f\u304c\u3042\u308b\u5834\u5408\u3001\u305d\u306e\u30ea\u30b9\u30af\u306f\u3055\u3089\u306b\u9ad8\u307e\u308a\u307e\u3059\u3002Muntner\u3089\u306b\u3088\u308bStroke\u8a8c\u306e\u7814\u7a76\u3067\u3082\u540c\u69d8\u306e\u7d50\u679c\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">8. \u591a\u56e0\u5b50\u4ecb\u5165\u306e\u6709\u52b9\u6027<\/h2>\n\n\n\n<p>**Steno-2 Study\u300cIntensive multifactorial intervention and cardiovascular outcomes in type 2 diabetes\u300d\uff08N Engl J Med. 2003\uff09**\u3067\u306f\u3001\u8840\u7cd6\u30fb\u8840\u5727\u30fb\u8102\u8cea\u30fb\u751f\u6d3b\u7fd2\u6163\u3092\u540c\u6642\u306b\u4ecb\u5165\u3059\u308b\u3053\u3068\u3067\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u304c50%\u4ee5\u4e0a\u6e1b\u5c11\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">9. SGLT2\u963b\u5bb3\u85ac \u2014 \u814e\u4fdd\u8b77\u3068\u5fc3\u8840\u7ba1\u30fb\u8133\u8840\u7ba1\u75be\u60a3\u30ea\u30b9\u30af\u306e\u4f4e\u6e1b<\/h2>\n\n\n\n<p><strong>\u300cCanagliflozin and Renal Outcomes in Type&nbsp;2 Diabetes and Nephropathy\u300d<\/strong>\uff08CREDENCE\u8a66\u9a13, N Engl J Med.&nbsp;2019\uff09\u3067\u306f\u3001\u7cd6\u5c3f\u75c5\u6027\u814e\u75c7\u3092\u4f75\u767a\u3057\u305f2\u578b\u7cd6\u5c3f\u75c5\u60a3\u80054,401\u4eba\u306b\u30ab\u30ca\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u3092\u6295\u4e0e\u3057\u305f\u7d50\u679c\u3001\u814e\u4e0d\u5168\u3084\u4e3b\u8981\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\uff08\u6b7b\u4ea1\u30fb\u5fc3\u7b4b\u6897\u585e\u30fb\u8133\u5352\u4e2d\uff09\u306e\u767a\u751f\u30ea\u30b9\u30af\u304c30\uff05\u4f4e\u4e0b\u3057\u305f\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7279\u306b\u3001\u5fc3\u4e0d\u5168\u5165\u9662\u30ea\u30b9\u30af\u306f39\uff05\u4f4e\u6e1b\u3057\u3001\u814e\u95a2\u9023\u6b7b\u304a\u3088\u3073\u672b\u671f\u814e\u4e0d\u5168\u306e\u30ea\u30b9\u30af\u308232\u301c34\uff05\u6e1b\u5c11\u3057\u3066\u3044\u307e\u3059 \u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001<strong>\u82f1\u56fd\u306e\u81e8\u5e8a\u8a66\u9a13\u5f8c\u306e\u30b5\u30d6\u89e3\u6790<\/strong>\u3067\u3082\u3001\u30ab\u30ca\u30b0\u30ea\u30d5\u30ed\u30b8\u30f3\u306f\u5c0f\u3055\u306a\u65b0\u898f\u8133\u5352\u4e2d\u30ea\u30b9\u30af\u306b\u3082\u6709\u76ca\u3067\u3042\u308b\u3068\u306e\u5831\u544a\u304c\u3042\u308a\u307e\u3059&nbsp;\u3002<\/p>\n\n\n\n<p>\u3055\u3089\u306b\u3001\u751f\u7406\u5b66\u7684\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066\u3001\u5229\u5c3f\u30fb\u964d\u5727\u4f5c\u7528\u3001\u30a2\u30eb\u30d6\u30df\u30f3\u5c3f\u306e\u6539\u5584\u3001\u305d\u3057\u3066\u5185\u76ae\u6a5f\u80fd\u3068\u7cd6\u4ee3\u8b1d\u6539\u5584\u304c\u76f8\u307e\u3063\u3066\u3001\u5168\u8eab\u6027\u306e\u8840\u7ba1\u4fdd\u8b77\u52b9\u679c\u3092\u767a\u63ee\u3059\u308b\u3053\u3068\u304c\u77e5\u3089\u308c\u3066\u3044\u307e\u3059&nbsp;\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">10. GLP\u20111\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac \u2014 \u65b0\u305f\u306a\u814e\u30fb\u5fc3\u30fb\u8133\u306e\u6cbb\u7642\u6f6e\u6d41<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Semaglutide\uff08\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\uff09<\/h3>\n\n\n\n<p>**\u300cEffects of Semaglutide on Chronic Kidney Disease in Patients with Type&nbsp;2 Diabetes\u300d\uff08FLOW\u8a66\u9a13, N Engl J Med.&nbsp;2024\uff09**\u3067\u306f\u3001\u6162\u6027\u814e\u81d3\u75c5\u3092\u5408\u4f75\u3057\u305f2\u578b\u7cd6\u5c3f\u75c5\u60a3\u80053,533\u4eba\u306b\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u3092\u6295\u4e0e\u3057\u305f\u3068\u3053\u308d\u3001\u4e3b\u8981\u814e\u30a4\u30d9\u30f3\u30c8\u304c24\uff05\u6e1b\u5c11\u3057\uff08HR&nbsp;0.76\uff09\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u308218\uff05\u6e1b\uff08HR&nbsp;0.82\uff09\u3001\u5168\u6b7b\u4ea1\u304c20\uff05\u6e1b\uff08HR&nbsp;0.80\uff09\u3068\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059 \u3002<\/p>\n\n\n\n<p>\u6b27\u5dde\u814e\u81d3\u5b66\u4f1a\uff08ERA\uff09\u5b66\u4f1a\u3067\u3082\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u306f\u814e\u75be\u60a3\u30a4\u30d9\u30f3\u30c8\u309224\uff05\u6e1b\u5c11\u3055\u305b\u3001\u5fc3\u8840\u7ba1\u6b7b\u3084\u814e\u6b7b\u306e\u30ea\u30b9\u30af\u3092\u3082\u8457\u3057\u304f\u4f4e\u4e0b\u3055\u305b\u308b\u3068\u8a55\u4fa1\u3055\u308c\u3066\u3044\u307e\u3059&nbsp;<a href=\"https:\/\/www.health.com\/ozempic-wegovy-chronic-kidney-disease-8655302?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noreferrer noopener\">researchgate.net+12health.com+12mediacenteratypon.nejmgroup-production.org+12<\/a>\u3002<\/p>\n\n\n\n<p>\u30bb\u30de\u30b0\u30eb\u30c1\u30c9\u306fGLP\u20111\u53d7\u5bb9\u4f53\u3092\u4ecb\u3057\u3066<strong>\u6162\u6027\u708e\u75c7\u3068\u5185\u76ae\u6a5f\u80fd\u6539\u5584<\/strong>\u3092\u3082\u305f\u3089\u3057\u3001\u307e\u305f\u4f53\u91cd\u6e1b\u5c11\u3084\u8840\u5727\u4f4e\u4e0b\u3001\u8102\u8cea\u6539\u5584\u3068\u3044\u3063\u305f\u591a\u9762\u7684\u52b9\u679c\u306b\u3088\u308a\u3001\u52d5\u8108\u786c\u5316\u6027\u75be\u60a3\u306e\u4e88\u9632\u306b\u3082\u5bc4\u4e0e\u3057\u307e\u3059&nbsp;\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">11. SGLT2\u963b\u5bb3\u85ac\uff0bGLP\u20111\u53d7\u5bb9\u4f53\u4f5c\u52d5\u85ac\u4f75\u7528\u306e\u52b9\u679c<\/h2>\n\n\n\n<p>\u6700\u65b0\u306e\u89e3\u6790\u3067\u306f\u3001SGLT2\u963b\u5bb3\u85ac\u3068GLP\u20111\u4f5c\u52d5\u85ac\u306e\u4f75\u7528\u306b\u3088\u3063\u3066\u3001\u814e\u30fb\u5fc3\u30fb\u8133\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u306e\u30ea\u30b9\u30af\u4f4e\u4e0b\u304c\u3055\u3089\u306b\u5f37\u5316\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u3066\u3044\u307e\u3059&nbsp;\u3002\u30e1\u30bf\u89e3\u6790\u306e\u57fa\u76e4\u3067\u3042\u308b\u751f\u7406\u30e1\u30ab\u30cb\u30ba\u30e0\u3068\u3057\u3066\u201c\u514d\u75ab\u8abf\u6574\u201d\u201c\u6297\u708e\u75c7\u201d\u201c\u8840\u7ba1\u4fee\u5fa9\u4fc3\u9032\u201d\u306e\u30b7\u30ca\u30b8\u30fc\u52b9\u679c\u304c\u671f\u5f85\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">12. \u708e\u75c7\u30fb\u5185\u76ae\u969c\u5bb3\u306e\u5171\u901a\u57fa\u76e4\u3068\u30ea\u30b9\u30af\u8efd\u6e1b\u6226\u7565<\/h2>\n\n\n\n<p>\u7cd6\u5c3f\u75c5\u6027\u814e\u75c7\u306e\u9032\u884c\u3068\u3068\u3082\u306b\u3001\u708e\u75c7\u30de\u30fc\u30ab\u30fc\uff08CRP\u3001IL\u20116\uff09\u3084\u8840\u7ba1\u5185\u76ae\u6a5f\u80fd\u969c\u5bb3\uff08\u8840\u7ba1\u53cd\u5fdc\u6027\u4f4e\u4e0b\uff09\u304c\u9855\u8457\u306b\u5897\u52a0\u3057\u307e\u3059&nbsp;\u3002SGLT2\u963b\u5bb3\u85ac\u3084GLP\u20111\u4f5c\u52d5\u85ac\u306f\u3053\u308c\u3089\u3092\u6291\u5236\u3057\u3001\u52d5\u8108\u786c\u5316\u9032\u5c55\u3092\u9045\u5ef6\u3055\u305b\u308b\u4f5c\u7528\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u708e\u75c7\u30fb\u5185\u76ae\u969c\u5bb3\u306f\u5fc3\u4e0d\u5168\u30fb\u8133\u5352\u4e2d\u30fb\u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b\u306e\u30ea\u30b9\u30af\u3068\u5bc6\u63a5\u306b\u95a2\u9023\u3057\u3066\u3044\u308b\u305f\u3081\u3001\u3053\u308c\u3089\u306e\u30a8\u30f3\u30c9\u30dd\u30a4\u30f3\u30c8\u304b\u3089\u306e\u4e88\u9632\u306f\u4e00\u77f3\u4e09\u9ce5\u306e\u610f\u5473\u3092\u6301\u3061\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">13. \u8a8d\u77e5\u6a5f\u80fd\u4f4e\u4e0b\u3068\u8133\u8840\u7ba1\u969c\u5bb3<\/h2>\n\n\n\n<p>\u6162\u6027\u814e\u75c7\u60a3\u8005\u3067\u306f\u9ed2\u8cea\u767d\u8cea\u75c5\u5909\u3084\u8133\u840e\u7e2e\u304c\u9032\u884c\u3057\u3001\u8a8d\u77e5\u6a5f\u80fd\u304c\u4f4e\u4e0b\u3057\u3084\u3059\u304f\u306a\u308a\u307e\u3059\u3002\u7279\u306b\u30a2\u30eb\u30d6\u30df\u30f3\u5c3f\u306e\u9032\u884c\u3068\u3068\u3082\u306b\u3001\u8a8d\u77e5\u75c7\u30ea\u30b9\u30af\u3082\u30a2\u30c3\u30d7\u3059\u308b\u3068\u306e\u5831\u544a\u3082\u3042\u308a\u3001\u3053\u308c\u306f\u8840\u7ba1\u6027\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u3088\u308b\u3068\u8003\u3048\u3089\u308c\u3066\u3044\u307e\u3059\u3002\u307e\u305f\u3001GLP\u20111\u4f5c\u52d5\u85ac\u306f\u4e2d\u67a2\u795e\u7d4c\u4fdd\u8b77\u4f5c\u7528\u3082\u793a\u5506\u3055\u308c\u3066\u304a\u308a\u3001\u8a8d\u77e5\u6a5f\u80fd\u306e\u6e29\u5b58\u52b9\u679c\u3082\u671f\u5f85\u3067\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">14. \u591a\u56e0\u5b50\u4ecb\u5165\u306e\u81e8\u5e8a\u7684\u6709\u52b9\u6027<\/h2>\n\n\n\n<p><strong>Steno\u20112 Study\u300cIntensive multifactorial intervention and cardiovascular outcomes in type&nbsp;2 diabetes\u300d<\/strong>\uff08N Engl J Med.&nbsp;2003\uff09\u3067\u306f\u3001\u8840\u7cd6\u30fb\u8840\u5727\u30fb\u8102\u8cea\u30fb\u751f\u6d3b\u7fd2\u6163\u306e\u591a\u56e0\u5b50\u4ecb\u5165\u306b\u3088\u308a\u3001\u5fc3\u8840\u7ba1\u30a4\u30d9\u30f3\u30c8\u309250%\u4ee5\u4e0a\u6e1b\u5c11\u3055\u305b\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f&nbsp;<a href=\"https:\/\/en.wikipedia.org\/wiki\/Semaglutide?utm_source=chatgpt.com\" target=\"_blank\" rel=\"noreferrer noopener\">clinicaltrials.gov+15en.wikipedia.org+15nature.com+15<\/a>\u3002<\/p>\n\n\n\n<p>\u73fe\u5728\u306f\u3055\u3089\u306b\u3001\u814e\u4fdd\u8b77\u85ac\uff08SGLT2\u963b\u5bb3\u85ac\u3001GLP\u20111\u4f5c\u52d5\u85ac\uff09\u3001\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u7cfb\u963b\u5bb3\u85ac\u3001MCR\u963b\u5bb3\u85ac\uff08\u30d5\u30a3\u30cd\u30ec\u30ce\u30f3\uff09\u3068\u3044\u3063\u305f\u85ac\u5264\u304c\u52a0\u308f\u308a\u3001\u3055\u3089\u306b\u591a\u9762\u7684\u306a\u4ecb\u5165\u304c\u53ef\u80fd\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">15. \u6cbb\u7642\u30a2\u30eb\u30b4\u30ea\u30ba\u30e0\u3068\u5b9f\u81e8\u5e8a\u3078\u306e\u5fdc\u7528<\/h2>\n\n\n\n<p>\u6700\u65b0\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\uff08ADA\u30fbKDIGO\u306a\u3069\uff09\u3067\u306f\u30012\u578b\u7cd6\u5c3f\u75c5\u6027CKD\u306e\u60a3\u8005\u306b\u306f<strong>\u5f37\u5316\u3055\u308c\u305f\u8840\u7cd6\u7ba1\u7406\uff08HbA1c&nbsp;\uff1c7.0\uff05\u307e\u305f\u306f\u500b\u5225\u5316\u76ee\u6a19\uff09<\/strong>\u3001<strong>\u8840\u5727\uff08130\/80mmHg\u4ee5\u4e0b\uff09<\/strong>\u3001<strong>LDL\u30b3\u30ec\u30b9\u30c6\u30ed\u30fc\u30eb<\/strong>\u304a\u3088\u3073<strong>\u30a2\u30f3\u30b8\u30aa\u30c6\u30f3\u30b7\u30f3\u7cfb\u963b\u5bb3\u85ac<\/strong>\u306b\u52a0\u3048\u3001<strong>SGLT2\u963b\u5bb3\u85ac<\/strong>\u3068<strong>GLP\u20111\u4f5c\u52d5\u85ac<\/strong>\u306e\u65e9\u671f\u5c0e\u5165\u304c\u63a8\u5968\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u307e\u305f\u3001<strong>\u55ab\u7159\u4e2d\u6b62\u30fb\u5869\u5206\u5236\u9650\u30fb\u9069\u5ea6\u306a\u904b\u52d5<\/strong>\u3082\u542b\u3081\u3001\u5305\u62ec\u7684\u306a\u751f\u6d3b\u7fd2\u6163\u6539\u5584\u3082\u4e0d\u53ef\u6b20\u3068\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">16. 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has-alpha-channel-opacity\"\/>\n\n\n\n<h2 class=\"wp-block-heading\">17. 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